CRAFT Hospital & Research Centre
Centre for Excellence in Infertility Treatment
IUI, IVF, ICSI, Medical Genetics, Andrology and Sexology,
Laproscopic Surgery & Neonatology

What's New @ Craft

CRAFT - PGD /PGS Medical Genetics Unit Starts Functioning

CRAFT – PGD /PGS Medical Genetics Unit Starts Functioning:

PGD/PGS is a process where a genetically normal embryo is selected, prior to its transfer to the uterine cavity by testing the chromosomes and DNA. This avoids abortions and hence results in successful pregnancy.

A wide variety of genetic problems in couples are often diagnosed at CRAFT. Couples, who have tried fertility treatments such as IVF/ICSI without PGD elsewhere, are now getting treated at CRAFT. Our team of experts now has answers to why failures have occurred in the past for these couples with a long history of treatment.  For example: Most of the affected couples are unaware of the reason why they couldn’t have a successful pregnancy. Here if the one of the parents have a chromosomal abnormality and the woman has had subsequent miscarriages, this chromosomal abnormality is the reason for failure. PGD enables this to be enlightened to the parents. Such category of cases belong to the immediate PGD group and need proper genetic counseling which will help them have a successful pregnancy   .  We have tailor made and customized protocols for almost all the genetic diseases/disorders and have pre-implantation screening options for couples. The major category of chromosomal defects is that of a balanced chromosomal translocation carrier status in any one of the parent. Balanced Chromosomal translocations means exchange of genetic material between any two chromosomes, this however results in a normal physical make but leads to many abortions when a couple is planning to have a baby . PGD in such cases will be relevant and beneficial. 90% of our PGD cases are for balanced chromosomal translocations.

Next category is for the diagnosis of single gene disorders. We are continuously dealing with couples who have had affected children or have had their children passed away due to fatal single gene or DNA related disorders. For example recently we diagnosed a couple with Spinal muscular atrophy TYPE 1 (SMN1) using our very latest technology of Quantitative real time fluorescence PCR .  The couple had lost their two children affected with this disorder. They came to CRAFT with a lot of hope. The sad part was that they were unaware of carrying the abnormal gene . We counseled the couple and told them that they both are the carriers (carry 50% abnormal genes) for spinal muscular atrophy and needs to opt for an IVF with PGD technique to help them have a normal child free from SMN 1 . Examples of situations when PGD could be considered include couples who have a 25% risk of having a child with a recessive genetic disease such as cystic fibrosis, spinal muscle atrophy or sickle cell anemia. Other examples include families who have a 50% risk to have a child with a dominant genetic disease such as Huntington’s disease or 25% risk for a sex-linked disease.

Couples especially in older women (advanced maternal age)  where there is a risk of a having a chromosomally abnormal pregnancy for example : trisomy 21 or down’s syndrome are being offered pre- implantation genetic screening. 

PGD/PGS has shown promising results in terms of pregnancy outcomes and fulfilling the dreams of parenthood for many parents who almost lost their hope to have a genetically healthy child. We are proud to be India’s one and only Centre to have a complete PGD set up.

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